兴奋性氨基酸作为中枢兴奋性神经递质,当其细胞外水平过高时,则具有神经毒性损伤作用。近年研究显示,兴奋性氨基酸在缺血性脑损伤中可能起重要作用;兴奋性氨基酸受体拮抗剂对该损伤具有明显的保护作用,可能成为临床治疗脑缺血的有效药物。本文就兴奋性氨基酸的神经毒性作用及其在缺血性脑损伤中的可能作用机理作一综述。 Excitatory amino acids as a central excitatory neurotransmitter, when its extracellular level is too high, then have a neurotoxic injury. Recent studies have shown that excitatory amino acids may play an important role in ischemic brain injury; excitatory amino acid receptor antagonists have a significant protective effect on the injury, which may become an effective drug for clinical treatment of cerebral ischemia. In this paper, the neurotoxicity of excitatory amino acids and its possible mechanism in ischemic brain injury are reviewed.