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目的:观察蠲痹历节清酊对小鼠脊髓反射和外周镇痛疗效的研究。方法:将30只SPF级健康雌性KM小鼠随机分成空白对照组、蠲痹历节清酊组、扶他林软膏组,每组10只。使用甩尾法检验扶他林软膏及蠲痹历节清酊抑制脊髓反射镇痛作用;使用醋酸扭体法检验扶他林软膏及蠲痹历节清酊的外周镇痛作用。结果:3组基础潜伏期相互比较,差异均无统计学意义(P>0.05);蠲痹历节清酊组与扶他林软膏组比较,甩尾潜伏期均较空白对照组长,扭体次数均较空白对照组少,差异均有统计学意义(P<0.05);蠲痹历节清酊组与扶他林软膏组甩尾潜伏期及扭体次数比较,差异均无统计学意义(P>0.05)。结论:蠲痹历节清酊具有一定的脊髓反射镇痛及外周镇痛效果。
OBJECTIVE: To observe the effect of Qingbi tincture on the spinal cord reflex and peripheral analgesia in mice. Methods: Thirty SPF healthy female KM mice were randomly divided into blank control group, Qingbi group, Fufarin ointment group, with 10 rats in each group. The use of flick-tail test Fufarin ointment and paralysis Qingliu tinnitus suppressive spinal analgesic effect; acetic acid writhing test Fudinglin ointment and paralysis Liqing Qing tincture of peripheral analgesic effect. Results: There was no significant difference in basal latency between the three groups (P> 0.05). Compared with the control group, the latency of tail flick was longer than that of the blank control group There was no significant difference between the control group and the control group (P <0.05). There was no significant difference in the latency and number of writhing in the group of Qingbi tincture and Fufailin ointment group (P> 0.05). Conclusion: Bi Biqing Qing tincture has some spinal reflex analgesia and peripheral analgesic effect.