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近年来研究表明,在Ⅰ型变态反应病人的血清中,不但能测出高滴度的抗原特异性IgE而且还可测出高滴度的特异性IgG,此抗体在哮喘的发病和诊断中有一定的意义。本文选择我院呼吸门诊治疗的80名外源性哮喘儿童,其中粉尘螨皮试阳性者53名,占66.25%。对这些儿童进行了螨特异性IgE和特异性IgG的测定,结果表明不仅螨特异性IgE抗体水平高于对照组,且螨特异性IgG抗体水平亦明显高于对照组。两者之间呈正相关,相关系数为0.746,与国外文献报告一致,提示特异性IgG在Ⅰ型变态反应的发病机理中可能起某种促进作用,对此本文作了初步探讨。同时说明血清螨特异性IgG水平可作为对螨过敏原诊断的一项参考指标。
In recent years, studies have shown that, in the type Ⅰ allergic patients serum, not only to detect high titer of antigen-specific IgE but also high titer specific IgG can be measured, the antibody in the pathogenesis and diagnosis of asthma A certain meaning. In this paper, 80 extrinsic asthmatic children were selected for treatment of respiratory clinic in our hospital. Among them, 53 were positive for dust mite skin test, accounting for 66.25%. Specific mite-specific IgE and specific IgG were measured in these children. The results showed that not only the mite-specific IgE antibody level was higher than that of the control group, but also the mite-specific IgG antibody level was significantly higher than that of the control group. There was a positive correlation between them, with a correlation coefficient of 0.746. Consistent with reports in foreign literature, it is suggested that specific IgG might play a role in promoting the pathogenesis of type Ⅰ allergic reaction. This article made a preliminary study. At the same time, the level of serum mite-specific IgG can be used as a reference for the diagnosis of mite allergen.