高血脂可加速动脉粥样硬化,促进炎症反应,减弱纤维蛋白溶解,从而导致冠心病。他汀类药物可通过降低胆固醇水平和非降脂作用减少心血管事件的发生。他汀治疗不仅可改善高胆固醇血症患者的内皮依赖性舒张功能和血栓形成前状态,而且可减少氧化应激和炎症标志物。近来证实,凝血酶激 Hyperlipidemia can accelerate atherosclerosis, promote inflammation, reduce fibrinolysis, leading to coronary heart disease. Statins reduce the incidence of cardiovascular events by lowering cholesterol levels and non-lipid-lowering effects. Statin therapy not only improves endothelium-dependent diastolic function and pre-thrombotic status in patients with hypercholesterolemia, but also reduces oxidative stress and inflammation markers. Recently confirmed that thrombin