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【目的】观察怒志对大鼠血管内皮功能及神经内分泌的影响。【方法】选用Wistar大鼠,随机分为正常对照组、愤怒模型组、孤独对照组。愤怒模型组大鼠单笼喂养,昼夜颠倒10d后,分别放入1只入侵鼠并进行行为学检测评分。模型复制成功后,采用放射免疫法检测各组大鼠血浆促肾上腺皮质激素(ACTH)、皮质醇(CORT)、内皮素(ET)、前列腺素(6-keto-PGFlα)水平。【结果】愤怒模型组行为学评分结果显示模型复制成功。孤独对照组和愤怒模型组血浆CORT、6-keto-PGFlα、ET水平显著升高,ACTH水平显著降低,与正常对照组比较差异有显著性意义(均P<0.01);愤怒模型组血浆6-keto-PGFla、ACTH水平与孤独对照组比较差异有显著性意义(均P<0.01)。【结论】情志因素可对神经内分泌水平及血管内皮功能产生一定的影响。
【Objective】 To observe the effect of Rushi on vascular endothelial function and neuroendocrine in rats. [Methods] Wistar rats were randomly divided into normal control group, anger model group, and lone control group. The rats in the anger model group were fed with a single cage and reversed day and night. After 10 days, they were put into an invader and scored for behavioral tests. After the model was replicated successfully, the levels of plasma adrenocorticotropic hormone (ACTH), cortisol (CORT), endothelin (ET), and prostaglandin (6-keto-PGFlα) were measured by radioimmunoassay. [Results] The ethnographic scoring results of the anger model group showed that the model was successfully reproduced. Plasma CORT, 6-keto-PGF1α, and ET levels were significantly increased in the Lonely control group and the anger model group, and the ACTH level was significantly decreased, showing a significant difference compared with the normal control group (all P<0.01); plasma in the anger model group 6- The levels of keto-PGFla and ACTH were significantly different from those in the control group (all P<0.01). 【Conclusion】Sentimental factors may have effects on neuroendocrine levels and endothelial function.