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干细胞是一类具有自我更新能力和多向分化潜能的原始细胞,干细胞的自我更新调节通路异常与肿瘤形成密切相关。恶性肿瘤的进行性生长、转移和复发与千细胞的基本特性相似, 推测在肿瘤组织中存在少数能驱使肿瘤形成与发展的肿瘤干细胞。随着近年来正常干细胞研究的飞速发展,肿瘤干细胞的研究取得了令人鼓舞的成果,急性髓细胞白血病、乳腺癌及脑瘤中的肿瘤干细胞已相继得到分离和鉴定。现对近年来肿瘤干细胞的研究进展作简要综述。
Stem cells are a group of primitive cells with self-renewal ability and multidirectional differentiation potential. The stem cell self-renewal regulatory pathways are closely related to tumor formation. The progressive growth, metastasis and recurrence of malignant tumors are similar to the basic characteristics of stem cells, suggesting that there are a few tumor stem cells in tumor tissues that can drive tumor formation and development. With the rapid development of normal stem cell research in recent years, the research of tumor stem cells has achieved encouraging results. Aneoplastic myeloid leukemia, breast cancer and tumor stem cells in brain tumors have been successively isolated and identified. The progress of cancer stem cells in recent years is briefly reviewed.