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对30例肝豆状核变性患者和20例正常对照者进行SPECT脑血流灌注显像,结果发现双侧豆状核r-CBF减低者30/30(100％),其中25/30例(83.3％)伴有弥漫性脑损害。临床表现和r-CBF改变有一定相关性,表明SPECT脑血流灌注显像有助于肝豆状核变性患者的诊断。
Thirty patients with Wilson’s disease and 20 normal control subjects underwent SPECT cerebral perfusion imaging. The results showed that 30/30 (100%) reduction of r-CBF in bilateral lentiform nuclei was found, of which 25/30 83.3%) with diffuse brain damage. Clinical manifestations and r-CBF changes have some relevance, indicating that SPECT cerebral perfusion imaging is helpful in the diagnosis of Wilson’s disease.