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[目的]分析报道大地震对SD大鼠生殖过程的影响,并探讨其可能的影响机制。[方法]试验选用SPF级成年健康SD大鼠,每天16～18时将雌雄大鼠按1︰1比例合笼过夜,d2早晨8～10时将雌雄大鼠分开,通过观察阴栓判断雌鼠是否交配,解剖20d龄孕鼠观察地震前后动物的受孕率、胎儿生长发育情况等指标。[结果]试验期间大鼠一般状况良好,与本实验室历史数据相比,动物交配率、受孕率差异有统计学意义(P﹤0.05)。对雌鼠、胎鼠外观和生长发育的影响差异无统计学意义(P﹥0.05)。[结论]地震对大鼠交配率、受孕率有明显影响,但对胎儿生长发育无明显影响。
[Objective] The research aimed to analyze the influence of large earthquakes on the reproductive process of SD rats and to explore its possible mechanism. [Methods] SPF adult healthy SD rats were selected. The female and male rats were caged at a ratio of 1: 1 from 16 to 18 days per day, and the male and female rats were separated from 8 to 10 on the morning of d2. Female mice Whether mating, dissecting 20d pregnant rats before and after the earthquake rate of pregnancy, fetal growth and development and other indicators. [Results] The rats were generally in good condition during the experiment. Compared with the historical data of the laboratory, the rate of mating and conception of animals was significantly different (P <0.05). There was no significant difference in the appearance and growth of female mice and fetuses (P> 0.05). [Conclusion] The earthquake had a significant effect on the mating rate and pregnancy rate in rats, but had no significant effect on fetal growth and development.