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目的分析雷贝拉唑三联疗法对活动期胃溃疡患者组织学愈合质量的影响。方法选取2013年10月—2016年6月收治的78例活动期胃溃疡患者,采用随机数字表法分为观察组和对照组各39例,观察组采用阿莫西林+克拉霉素+雷贝拉唑治疗,对照组采用阿莫西林+克拉霉素+奥美拉唑治疗,两组治疗7 d后均单独服用雷尼替丁21 d,比较两组溃疡愈合率、胃黏膜厚度、炎性细胞浸润、炎症活动性、腺体形态、腺体密度评分,数据采用SPSS18.0软件进行统计学处理。结果观察组溃疡总有效率94.87%高于对照组的79.49%,比较差异有统计学意义(χ2=4.129,P<0.05),观察组治疗后胃黏膜厚度、炎性细胞浸润、炎症活动性、腺体形态、腺体密度评分低于对照组,差异均有统计学意义(t=15.426、6.623、9.577、8.607、2.503,均P<0.05)。结论雷贝拉唑三联疗法应用于活动期胃溃疡患者,可显著提高溃疡愈合率,改善黏膜组织学情况,实用价值较高,值得推广和应用。
Objective To analyze the effect of rabeprazole triple therapy on histological healing of patients with active gastric ulcer. Methods Seventy-eight patients with active gastric ulcer admitted to our hospital from October 2013 to June 2016 were randomly divided into observation group (39 cases) and control group (39 cases). The observation group was treated with amoxicillin + clarithromycin + In the control group, amoxicillin + clarithromycin + omeprazole was used in the control group. Ranitidine alone was given for 21 days in both groups after 7 days of treatment. The ulcer healing rate, gastric mucosal thickness, inflammatory Cell infiltration, inflammatory activity, gland morphology, gland density score, the data using SPSS18.0 software for statistical analysis. Results The total effective rate of ulcer in observation group was 94.87%, which was significantly higher than 79.49% in control group (χ2 = 4.129, P <0.05). The thickness of gastric mucosa, inflammatory cell infiltration, inflammatory activity, Gland morphology, gland density score lower than the control group, the differences were statistically significant (t = 15.426,6.623,9.577,8.607,2.503, all P <0.05). Conclusion Rabeprazole triple therapy in patients with active gastric ulcer can significantly improve the healing rate of ulcers and improve mucosal histology, high practical value, it is worth promoting and application.