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目的探讨急慢性肾衰患者体内常见血清酶含量的变化及两者的差异性。方法急性肾衰（ＡＲＦ）和慢性肾衰（ＣＲＦ）患者及正常健康人３组各３０例，采用全自动生化分析仪检测血清中碱性磷酸酶（ＡＣＰ），淀粉酶（ＡＭＹ），肌酸激酶（ＣＫ）、乳酸脱氢酶（ＬＤＨ）及α一羟丁酸脱氢酶（ＨＢＤＨ）。结果（１）与正常健康人比较，急慢性肾衰患者血清ＡＭＹ、ＬＤＨ、ＨＢＤＨ均显著升高（Ｐ＜０．０１），ＣＫ次之（Ｐ＜０．０５）；血清ＡＬＰ在ＣＲＦ组明显升高（Ｐ＜０．０５），而ＡＲＦ组无显著差异（Ｐ＞０．０５）。（２）与ＣＲＦ组比较，ＡＲＦ组血清ＬＤＨ、ＨＢＤＨ明显升高（Ｐ＜０．０１），而ＡＭＹ、ＡＬＰ明显降低（Ｐ＜０．０１、Ｐ＜０．０５）；血清ＣＫ两组比较无显著差异（Ｐ＞０．０５）。结论血清ＡＬＰ、ＡＭＹ、ＬＤＨ和ＨＢＤＨ变化有助于临床上鉴别急、慢性肾衰。
Objective To investigate the changes of common serum enzymes in patients with acute and chronic renal failure and their differences. Methods Thirty patients with acute renal failure (ARF) and chronic renal failure (CRF) and 30 healthy controls were enrolled in this study. Serum levels of alkaline phosphatase (ACP), amylase (AMY), creatine (CK), lactate dehydrogenase (LDH) and alpha-hydroxybutyrate dehydrogenase (HBDH). Results (1) The levels of serum AMY, LDH and HBDH in acute and chronic renal failure patients were significantly higher than those in normal controls (P <0.01), followed by CK (P <0.05) (P <0.05), but there was no significant difference in ARF group (P> 0.05). (2) Serum LDH and HBDH in ARF group were significantly higher than those in CRF group (P <0.01), but AMY and ALP were significantly lower (P <0.01, P <0.05) No significant difference (P> 0.05). Conclusion The changes of serum ALP, AMY, LDH and HBDH are helpful to differentiate acute and chronic renal failure clinically.