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目的探讨急慢性肾衰患者体内常见血清酶含量的变化及两者的差异性。方法急性肾衰(ARF)和慢性肾衰(CRF)患者及正常健康人3组各30例,采用全自动生化分析仪检测血清中碱性磷酸酶(ACP),淀粉酶(AMY),肌酸激酶(CK)、乳酸脱氢酶(LDH)及α一羟丁酸脱氢酶(HBDH)。结果(1)与正常健康人比较,急慢性肾衰患者血清AMY、LDH、HBDH均显著升高(P<0.01),CK次之(P<0.05);血清ALP在CRF组明显升高(P<0.05),而ARF组无显著差异(P>0.05)。(2)与CRF组比较,ARF组血清LDH、HBDH明显升高(P<0.01),而AMY、ALP明显降低(P<0.01、P<0.05);血清CK两组比较无显著差异(P>0.05)。结论血清ALP、AMY、LDH和HBDH变化有助于临床上鉴别急、慢性肾衰。
Objective To investigate the changes of common serum enzymes in patients with acute and chronic renal failure and their differences. Methods Thirty patients with acute renal failure (ARF) and chronic renal failure (CRF) and 30 healthy controls were enrolled in this study. Serum levels of alkaline phosphatase (ACP), amylase (AMY), creatine (CK), lactate dehydrogenase (LDH) and alpha-hydroxybutyrate dehydrogenase (HBDH). Results (1) The levels of serum AMY, LDH and HBDH in acute and chronic renal failure patients were significantly higher than those in normal controls (P <0.01), followed by CK (P <0.05) (P <0.05), but there was no significant difference in ARF group (P> 0.05). (2) Serum LDH and HBDH in ARF group were significantly higher than those in CRF group (P <0.01), but AMY and ALP were significantly lower (P <0.01, P <0.05) No significant difference (P> 0.05). Conclusion The changes of serum ALP, AMY, LDH and HBDH are helpful to differentiate acute and chronic renal failure clinically.