论文部分内容阅读
多发性骨髓瘤(MM)是一种浆细胞异常增生的恶性肿瘤,在美国每年死亡人数约为1万人,占恶性肿瘤死亡的1％,我国的发病率亦有逐年增加的趋势。临床起病隐匿,呈进行性加重。主要表现为骨骼疼痛、病理性骨折、贫血、高钙血症、肾损害、反复感染等。其并发症的性质和严重性,药物治疗的敏感性及其病程,在患者中有很大差异,特殊的实验室检查对诊断、病程分期,对需治疗的各种合并症的鉴别和对浆细胞数变化的估价均是必需的。本文综述孤立性浆细胞瘤、隐性多发性骨髓瘤和显性多发性骨髓瘤的治疗原则。
Multiple myeloma (MM) is a kind of malignant tumor with abnormal proliferation of plasma cells. The number of deaths in the United States is about 10,000 each year, accounting for 1% of the deaths from malignant tumors. The incidence rate in China is also increasing year by year. The onset of clinical occultation was progressively worsening. Mainly manifested as bone pain, pathological fractures, anemia, hypercalcemia, kidney damage, recurrent infections. The nature and severity of its complications, the sensitivity of the drug treatment, and the course of the disease are very different among patients. Special laboratory tests are used for diagnosis, disease progression, identification of various complications to be treated, and sizing Changes in the number of cells are all required. This article reviews the principles of treatment for solitary plasmacytoma, latent multiple myeloma, and dominant multiple myeloma.