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目的:探讨CA199、CEA和CA2424种肿瘤标志物单独检测或联合检测在胰腺癌诊断中的价值。方法:检测我院2005年1月～2012年10月期间收治的96例胰腺癌患者、133例胰腺炎患者和1300例健康体检者血清中CA199、CEA和CA242水平。结果:胰腺癌患者血清中CA199、CEA和CA242水平明显高于胰腺炎及正常对照组(P<0.05)。单项检测中血清CA199的敏感性最高,达94.6%,而联合检测CA199+CEA+CA242的特异性最高,达98.9%。结论:单项检测CA199可以提高胰腺癌诊断的敏感性,联合检测CA199+CEA+CA242可以提高胰腺癌诊断的特异性。
Objective: To investigate the value of CA199, CEA and CA2424 tumor markers in the diagnosis of pancreatic cancer by single or combined detection. Methods: The serum levels of CA199, CEA and CA242 in 96 patients with pancreatic cancer, 133 patients with pancreatitis and 1300 healthy controls were detected in our hospital from January 2005 to October 2012. Results: Serum levels of CA199, CEA and CA242 in patients with pancreatic cancer were significantly higher than those in pancreatitis and normal controls (P <0.05). The highest sensitivity of serum CA199 in single test was 94.6%, while the specificity of combined detection of CA199 + CEA + CA242 was 98.9%. Conclusion: Single detection of CA199 can improve the diagnostic sensitivity of pancreatic cancer. Combined detection of CA199 + CEA + CA242 can improve the specificity of diagnosis of pancreatic cancer.