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作者根据肌酐是骨骼肌和心肌的一种主要成份,且分子量低(Mr131),因此一旦细胞损伤就能迅速进入血浆,随即一部份从尿中排出,而提出用酶法测定尿肌酐以早期诊断急性心肌梗塞(AMI)。作者用Suzuki-yoshida二氏酶法(因此法不受头孢子菌素和肌酸干扰,且能自动化),对20例AMI进行了观察。发现其早期有一过性血清肌酐升高。在疼痛发作后8小时可有12.8(SD_3.6)毫克/升的峰值;而正常对照为5.4±1.8毫克/升(P<0.01)。随后8小时又逐渐下降。同时尿中肌酐也明显增高,在血清峰值后30分钟达到最高峰范围在80-500毫克/升之间;而正常对照仅为1.5-10.0
According to creatinine is a main component of skeletal muscle and myocardium, and low molecular weight (Mr131), so once the cell damage can quickly enter the plasma, then part of the discharge from the urine, and proposed enzymatic determination of urinary creatinine early Diagnosis of acute myocardial infarction (AMI). The authors used 20 Suzuki-yoshida enzyme method (so the method is not subject to cephalosporin and creatine interference, and can be automated), 20 cases of AMI were observed. Found that its early transient serum creatinine increased. There was a peak of 12.8 (SD 3.6) mg / L at 8 hours after the onset of the pain; whereas the normal control was 5.4 1.8 mg / L (P <0.01). After 8 hours and then gradually declined. At the same time, urinary creatinine was also significantly higher in the serum peak 30 minutes to reach the peak in the range of 80-500 mg / l; while the normal control was only 1.5-10.0