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N-甲基靛红-β-4′:4′-二乙基缩氨硫脲(M-IBDET)是九种缩氨硫脲衍生物中唯一能特异性抑制Moloney白血病病毒(MLV)增殖的化合物。本文研究了M-IBDET对细胞内MLV的逆转录酶活性、病毒RNA水平及结构蛋白合成的影响。作者以逆转录酶活性作为MLV在细胞内增殖的指标,检测不同浓度的M-IBDET对MLV在3T3/MLV细胞内增殖的抑制率。3T3/MLV是1株用MLV慢性感染的小鼠
N-methylisatin-β-4′:4′-diethylthiosemicarbazone (M-IBDET) is the only compound capable of specifically inhibiting the proliferation of Moloney leukemia virus (MLV) in nine thiosemicarbazide derivatives. Compound. This study investigated the effects of M-IBDET on reverse transcriptase activity, viral RNA levels, and structural protein synthesis of intracellular MLV. The authors used reverse transcriptase activity as an indicator of MLV proliferation in cells, and examined the inhibitory rate of M-IBDET at different concentrations on the proliferation of MLV in 3T3/MLV cells. 3T3/MLV is a mouse chronically infected with MLV