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目的:观察拉莫三嗪(LTG)治疗老年癫痫部分性发作(PS)或继发全面性发作(SGTCS)的疗效和安全性。方法:80例老年PS或SGTCS患者随机分为观察组和对照组,每组40例。观察组患者口服拉莫三嗪治疗12个月,对照组口服丙戊酸钠治疗12个月。观察两组患者的疗效和安全性。结果:观察组总有效率为92.5%,高于对照组的77.5%;药品不良反应发生率为7.5%,低于对照组的15.0%,差异均有统计学意义(P<0.05)。结论:拉莫三嗪治疗老年癫痫PS或SGTCS癫痫安全、有效。
Objective: To observe the efficacy and safety of lamotrigine (LTG) in the treatment of partial seizures (PS) or secondary total seizures (SGTCS) in elderly patients. Methods: Eighty elderly patients with PS or SGTCS were randomly divided into observation group and control group, 40 cases in each group. Patients in the observation group were treated with oral lamotrigine for 12 months and those in the control group were treated with sodium valproate for 12 months. The efficacy and safety of the two groups were observed. Results: The total effective rate in the observation group was 92.5%, which was higher than that in the control group (77.5%). The adverse reaction rate was 7.5% in the observation group, which was lower than 15.0% in the control group (P <0.05). Conclusion: Lamotrigine is safe and effective in the treatment of senile epilepsy PS or SGTCS epilepsy.