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目的:探讨胃肠间质瘤(GIST)临床病理特征与分类。方法:选择2015年2月至2106年2月重庆市渝北区人民医院接受治疗并经病理学确诊为GIST的80例患者的临床病理资料和肿瘤组织标本,采用免疫组化S-P染色法检测肿瘤组织标本中CD117、DOG1、CD34、S-100、SMA的表达情况,统计分析临床病理特征。结果:梭形细胞型57例,上皮样细胞型9例,混合型14例。CD117阳性表达率为93.75%,DOG1阳性表达率为87.5%,CD34阳性表达率为75%,阳性表达率最小的为S-100。结论:GIST的组织学分类可分为梭形细胞型、上皮样细胞型、混合型3类,GIST中CD117、DOG1蛋白阳性表达率较高,是诊断GIST的重要标记物,GIST原发部位以胃和小肠最为常见。
Objective: To investigate the clinicopathological features and classification of gastrointestinal stromal tumors (GIST). Methods: The clinical and pathological data and tumor tissue samples from 80 patients who were treated by Yubei District People’s Hospital of Chongqing from February 2015 to February 2006 were retrospectively analyzed. The immunohistochemical SP staining was used to detect the tumor The expression of CD117, DOG1, CD34, S-100 and SMA in the tissue samples were statistically analyzed for clinical and pathological features. Results: There were 57 spindle cell type, 9 epithelial cell type and 14 mixed type. The positive expression rate of CD117 was 93.75%, the positive expression rate of DOG1 was 87.5%, the positive expression rate of CD34 was 75%, and the lowest positive expression rate was S-100. Conclusion: The histological classification of GIST can be divided into three types: spindle cell type, epithelioid cell type and mixed type. The positive expression rate of CD117 and DOG1 in GIST is an important marker for the diagnosis of GIST. The primary site of GIST The most common stomach and small intestine.