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3-溴乙酰基吡啶经DMSO氧化制得吡啶基乙酮醛,不经纯化,与乙酸铵和甲醛经Debus-Radziszewski环合反应制得泰利霉素侧链4-(3-吡啶基)-1H-咪唑,总收率约66%。
The 3-bromoacetylpyridine was oxidized by DMSO to give pyrido-Ketone aldehyde. Without purification, the telithromycin side chain 4- (3-pyridyl) -1H was obtained by cyclization reaction of ammonium acetate and formaldehyde with the method of Debus-Radziszewski - imidazole, the total yield of about 66%.