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目的:观察丹红注射液对高脂血症患者内皮功能及C反应蛋白的影响。方法:将高脂血症84例,随机分为观察组和对照组各42例。对照组采用氟伐他汀治疗,每次40 mg,每晚1次;观察组在对照组治疗基础上加用丹红注射液30 ml,加入到5%葡萄糖或生理盐水250 ml中静脉滴注,每天1次。两组均治疗15天。比较两组治疗前后血管内皮功能、血脂及C反应蛋白(CRP)水平的变化。结果:两组治疗后内皮功能相关指标血流介导的内皮依赖性舒张功能、氧化亚氮、内皮素-1及血脂、CRP水平差异显著(P<0.05)。结论:丹红注射液加氟伐他汀,改善内皮依赖性血管舒张功能及减轻炎症反应的效果优于单纯氟伐他汀。
Objective: To observe the effect of Danhong Injection on endothelial function and C-reactive protein in patients with hyperlipidemia. Methods: 84 cases of hyperlipidemia were randomly divided into observation group and control group, 42 cases each. The control group was treated with fluvastatin, 40 mg once each night. The observation group was given Danhong injection 30 ml on the basis of the control group, added intravenously to 250 ml of 5% dextrose or normal saline, 1 day. Both groups were treated for 15 days. The changes of vascular endothelial function, blood lipid and C-reactive protein (CRP) before and after treatment were compared between the two groups. Results: Endothelium - dependent vasodilatation, nitric oxide, endothelin - 1, blood lipids and CRP level were significantly different between the two groups (P <0.05). CONCLUSION: Danhong injection combined with fluvastatin improves endothelium-dependent vasodilation and relieves inflammation more effectively than fluvastatin alone.