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目的:探讨无创机械通气辅助中西医结合疗法治疗AECOPD对患者血清相关因子水平的影响。方法:收集2012年3月~2014年12月来我院就诊的患者200例,随机分为试验组和对照组,每组100例。所有患者均给予无创机械通气和纳洛酮治疗,试验组额外给予自拟活血化瘀方治疗,观察两组患者治疗后血清相关因子水平变化。结果:试验组患者治疗后3d、7d和14d血清IL-18、和肽素及CRP水平均低于对照组,分别经t检验比较,差异均具有统计学意义(P<0.05)。结论:无创机械通气辅助中西医结合疗法治疗AECOPD可显著降低患者血清IL-18、和肽素及CRP水平。
Objective: To investigate the effect of non-invasive mechanical ventilation-assisted traditional Chinese and western medicine on the serum level of AECOPD in patients. Methods: A total of 200 patients admitted to our hospital from March 2012 to December 2014 were randomly divided into experimental group and control group, with 100 cases in each group. All patients were given noninvasive mechanical ventilation and naloxone treatment. The experimental group was additionally given self-made blood-activating and stasis-removing prescriptions, and the changes of serum-related factors after treatment were observed in both groups. Results: The levels of IL-18, Copeptin and CRP in the experimental group were significantly lower than those in the control group on the 3rd, 7th and 14th day after treatment. The differences were statistically significant (P <0.05) by t-test. Conclusion: Noninvasive mechanical ventilation assisted with traditional Chinese and western medicine in the treatment of AECOPD can significantly reduce the serum IL-18, Copeptin and CRP levels.