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中西杀灭菊酯(S5602)和中西除虫菊酯(S5439)是上海第14制药厂试产的两种拟除虫菊酯类新型杀虫剂。它具有杀虫谱广、用量小、对人畜毒性低等优点。为了全面评价农药中西杀灭菊酯和中西除虫菊酯的安全性,我们进行了小白鼠骨髓细胞染色体的畸变试验。试验结果表明,小白鼠的给药剂量在1/10LD50以下,染色体畸变细胞率很低(0.57％～0.67％)和对照组比较无显著差异。这从细胞遗传学效应上证明了中西杀灭菊酯和中西除虫菊酯确是毒性较低的农药。
The Chinese and Western phytosteril (S5602) and Sino-Thyroid pyrethroid (S5439) are two novel pyrethroid insecticides produced by Shanghai No. 14 Pharmaceutical Factory. It has the advantages of wide insecticidal spectrum, small amount, and low toxicity to humans and animals. In order to fully evaluate the safety of the pesticides, cypermethrin and pyrethroids, we performed chromosome aberration tests on bone marrow cells in mice. The experimental results showed that mice administered at doses below 1/10LD50, and the rate of chromosomal aberrations cells was very low (0.57% to 0.67%) was not significantly different from the control group. This demonstrates from the cytogenetic effect that the Chinese and Western cypermethrin and the pyrethroids are indeed low toxicity pesticides.