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受试着为6名健康青年男性(20～24岁),于海平面和进入肯尼亚山(4 459m)后的第1～2、8～9～及15～16天,每隔1小时收集1次唾液。测量其内醛固酮(SA)及糖皮质激素(SGC,包括皮质醇和脱氢皮质酮)的浓度,同时采集静脉血,分析血中两种激素的含量。结果发现,不管在海平面还是高原,血浆和唾液的醛固酮及糖皮质激素浓度均具有高度相关(r值分别为0.91和0.75,p<0.01);进入4 450m后,首次收集的唾液SA的平均浓度约为海平面值的50％(P<0.05),而且在高原停留的整各时期内(2周)基本恒定在这一水平;然而,SA的浓度随时间(小时)变化的模式与海平面条件下的相比主要差别是:正常情况下在海平面起床后最初几小时出现的SA明显增加的特点,进
Six healthy young men (20-24 years old) were enrolled in the study. They were collected every 1 hour on the sea level and 1 ~ 2,8 ~ 9 ~ and 15 ~ 16 days after entering Mount Kenya (4 459m) saliva. The concentrations of aldosterone (SA) and glucocorticoids (SGC, including cortisol and corticosterone) were measured. Meanwhile, venous blood was collected for the analysis of two hormones in the blood. The results showed that aldosterone and glucocorticoid concentrations in plasma and saliva were highly correlated at both sea level and plateau (r values were 0.91 and 0.75, p <0.01, respectively); after 4 450 m, saliva SA first collected The concentration was approximately 50% of the sea level (P <0.05) and remained constant at this level throughout the period of plateau residence (2 weeks); however, the pattern of SA concentration over time (hours) The main difference compared to the conditions is the marked increase in SA that normally occurs in the first few hours after sea level rise,