肾脏纤维化是局灶性硬化性肾炎等各种肾小球肾炎晚期的共同病理特征,也是高血压、糖尿病等多种慢性疾病进行性肾功能丧失的最后结局。在此病理改变过程中,约占肾小球固有细胞总数30%~40%的系膜细胞发挥着重要作用。本文就系膜细胞与肾脏纤维化关系的最新研究作一综述。1系膜细胞基本结构与功能 Renal fibrosis is a common pathological feature of various forms of glomerulonephritis, such as focal sclerosing nephritis, and is also the final outcome of progressive renal dysfunction of various chronic diseases such as hypertension and diabetes. In this process of pathological changes, about the total number of glomerular intrinsic cells of 30% to 40% of mesangial cells play an important role. This article reviews the recent studies on the relationship between mesangial cells and renal fibrosis. 1 mesangial cells basic structure and function