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统计1985年前10年间35例晚期鼻及鼻窦肿瘤病人,分析包括区域动脉灌注化疗的综合疗法的效果,上皮源癌肿31例,非上皮源性4例,年龄25～76岁,男26,女9;原发灶鼻腔3例,筛窦19例,上颌窦12例,额窦1例。首次治疗9例,放疗后化疗10例,放疗和/或术后复发16例。3例为T_3N_0M_0,27例为T_4N_0M_0,1例为T_4N_2M_0,4例未能分期。区域性动脉内灌注化疗药物首选博莱霉素(每日15mg,总量300mg),其次有甲氨喋呤(每日10mg,总量150～200mg)、噻替哌(每日10mg,总量150～200mg)、顺铂(一次10mg,总量100～120mg);31例同时接受2种药物。黑素瘤用(?)每日2次,每次50mg,总量达2g;
Statistics of 35 patients with advanced nasal and paranasal sinus tumors during the first 10 years of 1985 were analyzed. The effects of comprehensive therapies including regional arterial infusion chemotherapy were analyzed. There were 31 epithelial cancers and 4 non-epithelial origins, aged 25 to 76 years, and 26 men. Female 9; primary nasal cavity in 3 cases, ethmoid sinus in 19 cases, maxillary sinus in 12 cases, frontal sinus in 1 case. Nine cases were treated for the first time, 10 cases were treated with chemotherapy after radiotherapy, and 16 cases were treated with radiotherapy and/or postoperative recurrence. Three cases were T_3N_0M_0, 27 cases were T_4N_0M_0, and 1 case was T_4N_2M_0. Four cases failed to be staged. Bleomycin (15 mg daily, total 300 mg) is preferred for regional intra-arterial infusion of chemotherapeutic drugs, followed by methotrexate (10 mg daily, total 150-200 mg), thiotepa (10 mg daily, total 150-200 mg), cisplatin (10 mg once, total 100-120 mg); 31 patients received both drugs at the same time. Melanoma with (?) 2 times a day, each time 50mg, a total of 2g;