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同一药物制成不同剂型的口服药剂进入人体后药物发挥效力的速度受药物制剂因素的影响而有所不同,一般溶液剂>混悬剂>散剂>胶囊剂、片剂,已是众所周知。在口服药液中有时为了保护消化道粘膜、矫味等目的,常在溶液剂中添加高分子、粘性物质制成胶浆剂、糖浆剂等,这些口服液体药剂的胃肠吸收速率的差异及对临床疗效的影响,虽有文献提及,但在实际工作中有时常被疏忽。如:临床至今仍常用的速效催眠药水合氯醛,以往我们均以10％水合氯醛溶液供病人服用,效果肯定,一般在服用半小时内均能入眠。以后我们为了减少水合氯醛对消化道粘膜刺激和矫味,参考了国内文献上介绍的处方,将水合氯醛溶液改制成6.5％水合氯醛、溴化钠琼脂糖浆剂供病人服用,一些老病人普遍反映琼脂糖浆剂效果不如溶液剂,不能达到迅速入眠的要求,宁可仍要味道不好的溶液剂,后来我们又将水合氯醛溶液加入0.5％羧甲基纤维素钠制成10％水合氯醛胶浆剂,老病人使用后反映效果仍不好,为了探讨水合氯醛溶液改变处方后病人反映效果不好的原因,我们做了将同一药物制成三种不同类型的口服
The same drug made of different dosage forms of oral agents into the human body after the drug effectiveness of the drug by the factors that affect the different, general solution> suspension> powder> capsules, tablets, is well known. Oral liquid sometimes in order to protect the digestive tract mucosa, taste and other purposes, often in the solution to add polymers, viscous substances made of glue, syrup, etc., these oral liquid medicine gastrointestinal absorption rate differences and Although the impact of clinical efficacy, although mentioned in the literature, but in actual work is often overlooked. Such as: clinical still commonly used quick-acting hypnotic drugs chloral hydrate, we used to 10% chloral hydrate solution for the patient, the effect is affirmative, usually within half an hour can take a nap. After we in order to reduce the chloral hydrate gastrointestinal mucosa stimulation and taste, with reference to the literature described in the literature, the chloral hydrate solution into 6.5% chloral hydrate, sodium bromide agar syrup for the patient to take some old Patients generally reflect the effect of agar syrup is not as good as solution, can not achieve the requirements of rapid sleep, prefer to still taste bad solution, then we will chloral hydrate solution by adding 0.5% sodium carboxymethyl cellulose made of 10% hydration Chloral hydration agent, the old patients after the use of the reaction is still not good, in order to explore the chloral hydrate solution to change the prescription after the patient to reflect the effect is not good, we made the same drug made into three different types of oral