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多年来利尿药在高血压阶梯治疗方案中被列为首选药物,近年发现长期服用可增加冠心病发病的危险性。α_1受体阻断药哌唑嗪具有副作用小,不引起肾素释放,不影响心率、心输出量、肾血流量、血糖、血尿酸、脂类代谢及性机能等而优于其他降压药。对轻中重各型各类高血压效果良好,也适用于高血压合并肾功能不全、心脏传导阻滞、高脂血症、糖尿病及高尿酸血症等,同样也适于急性心肌梗塞后顽固性心力衰竭及冠心病心绞痛。是一种可以替代利尿药及β阻断药的较理想的一线首选降压药。
Over the years diuretics in the treatment of hypertension ladder program was listed as the drug of choice, in recent years found that long-term use can increase the risk of coronary heart disease. α_1 receptor blocker prazosin has less side effects, does not cause renin release, does not affect heart rate, cardiac output, renal blood flow, blood glucose, serum uric acid, lipid metabolism and sexual function, but superior to other antihypertensive drugs . On all kinds of light and heavy type of various types of high blood pressure effect is good, also applies to hypertension with renal insufficiency, heart block, hyperlipidemia, diabetes and hyperuricemia, also applies to stubborn after acute myocardial infarction Heart failure and coronary heart disease angina. Is an alternative to diuretics and β-blocker of the ideal first-line preferred antihypertensive drugs.