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采用亚慢性动物实验方法，研究了氟、砷及其联合作用对大鼠肝脏ＳＯＤ、ＧＳＨ－Ｐｘ活性及ＭＤＡ、－ＳＨ含量的影响。结果显示：各实验组大鼠肝脏ＭＤＡ含量无明显差别，但染氟组（１５０ｍｇ／Ｌ，ＮａＦ）和染砷组（７５ｍｇ／Ｌ，Ａｓ２Ｏ３）ＳＯＤ、ＧＳＨ－Ｐｘ活性和－ＳＨ含量明显地低于对照组和氟砷联合组，后两组之间ＳＯＤ、ＧＳＨ－Ｐｘ活性无明显差异，氟砷联合组的－ＳＨ含量低于对照组。提示：氟和砷均可使肝脏的抗氧化能力降低；氟与砷同时存在时（氟、砷毒物剂量比为２：１），对肝脏ＳＯＤ、ＧＳＨ－Ｐｘ活性和－ＳＨ含量的影响存在拮抗作用，但对－ＳＨ的拮抗影响较弱。由于氟和砷之间的拮抗效应，使其联合作用对肝脏抗氧化能力的影响低于单纯氟和单纯砷。
The effects of fluoride, arsenic and their combined effects on the activities of SOD and GSH-Px and the contents of MDA and -SH in the liver of rats were studied by subchronic animal experiments. The results showed that there was no significant difference in the content of MDA in the liver of each experimental group, but SOD and GSH-Px activity and -SH content in the groups exposed to fluoride (150mg / L, NaF) and arsenic (75mg / L, As2O3) There was no significant difference in the activity of SOD and GSH-Px between the control group and fluoride-arsenic combination group, and the content of -SH in fluoride-arsenic combination group was lower than that of the control group. It is suggested that both fluoride and arsenic can reduce the antioxidant capacity of the liver. In the presence of both arsenic and fluoride, the dose ratio of fluoride to arsenic is 2: 1, and there is antagonism on the activity of SOD, GSH-Px and the content of -SH However, the antagonism of -SH is weak. Due to the antagonistic effect between fluoride and arsenic, the combined effect of the combination on the antioxidant capacity of the liver is lower than pure fluorine and simple arsenic.