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目的：观察１（２，６二甲基苯氧基）２（３，４二甲氧基苯乙胺基）丙烷盐酸盐（ＤＤＰＨ）对实验性高血压大鼠血管平滑肌细胞（ＶＳＭＣ）增殖的作用及对生长因子ＰＤＧＦＢ，ｂＦＧＦ及其相关癌基因ｃｓｉｓ，ｃｍｙｃ表达的影响。方法：采用氚胸腺嘧啶核苷（３ＨＴｄＲ）掺入法，电镜，免疫组化，原位杂交法进行实验观察。结果：ＤＤＰＨ在降低血压同时，能减少ＶＳＭＣ的线粒体，粗面内质网和３ＨＴｄＲ掺入量，并能逆转ＶＳＭＣ增殖时ＰＤＧＦＢ，ｂＦＧＦ抗原及ｃｓｉｓ，ｃｍｙｃｍＲＮＡ的表达增强。结论：ＤＤＰＨ能抑制实验性高血压大鼠的ＶＳＭＣ增殖，与生长因子及癌基因调控的分子生物学机制有关。
Objective: To observe the effects of 1 (2,6-dimethylphenoxy) 2 (3,4-dimethoxyphenethyl) propane hydrochloride (DDPH) on vascular smooth muscle in experimental hypertensive rats (VSMC) proliferation and the effect on growth factor PDGF B, bFGF and its related oncogene csis and cmyc expression. Methods: Tritium thymidine incorporation (3H TdR) incorporation, electron microscopy, immunohistochemistry, in situ hybridization experiments were observed. Results: DDPH can reduce the amount of mitochondria, rough endoplasmic reticulum and 3H-TdR incorporation in VSMC while decreasing blood pressure, and can reverse the expression of PDGF-B, bFGF antigen and c-sis, c-mycmRNA in VSMC proliferation . Conclusion: DDPH can inhibit VSMC proliferation in experimental hypertensive rats, which is related to the molecular biological mechanism of growth factors and oncogenes regulation.