小猎兔犬16条,雌雄各半,分为3个用药组及对照组,分别喂服100,300和1000μg/kg的米索前列醇和橄榄油,均qd给药,连续30d。每10d测定血、尿常规,血液生化指标和心电图。d30半数处死,2wk后另半数处死,测定重要器官的脏器系数,并进行组织学检查。结果:用药组睾丸、附睾萎缩明显,睾丸生精细胞消失,停药2wk未见恢复。 Beagle dogs 16, male and female, divided into three groups and the control group were fed 100, 300 and 1000μg / kg of misoprostol and olive oil, qd administration for 30 days. Blood, urine, blood biochemistry and electrocardiogram were measured every 10 days. Half of d30 was sacrificed and sacrificed after 2wk. The organ coefficients of vital organs were determined and histological examination was performed. Results: Testicular and epididymal atrophy were obvious in test group and no spermatogenic cells in testis disappeared.