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目的:探讨连续性血液净化(CBP)治疗重症急性有机磷农药中毒(ASOPP)的临床效果。方法:将2009年7月至2012年12月我科收治的ASOPP患者56例随机分为治疗组及对照组各28例,所有患者常规给予洗胃、导泻、补液、使用阿托品和胆碱酯酶复能剂、气管插管、呼吸机辅助呼吸等综合治疗,入ICU后即给予血液灌流1次,治疗组连续3天CBP治疗,比较两组在ICU天数、胆碱酯酶活力恢复时间、昏迷时间及死亡率。结果:与对照组比较,治疗组在ICU天数缩短、胆碱酯酶活力恢复快、昏迷时间缩短和死亡率降低,差异有统计学意义(P<0.05)。结论:对ASOPP患者,在常规救治基础上辅以CBP治疗能持续清除体内毒物,缩短病程,降低患者死亡率。
Objective: To investigate the clinical effect of continuous blood purification (CBP) on severe acute organophosphorus pesticide poisoning (ASOPP). Methods: From July 2009 to December 2012, 56 ASOPP patients admitted to our department were randomly divided into treatment group (n = 28) and control group (n = 28). All patients were given routine gastric lavage, catharsis and rehydration. Atropine and choline Enzyme rehabilitation agent, endotracheal intubation, ventilator assisted breathing and other integrated treatment, into the ICU after hemoperfusion once given, the treatment group for 3 consecutive days of CBP treatment, the two groups in the ICU days, the recovery time of cholinesterase activity, Coma time and mortality. Results: Compared with the control group, the treatment group had shorter ICU days, faster recovery of cholinesterase activity, shorter coma time and lower mortality, the difference was statistically significant (P <0.05). Conclusion: For ASOPP patients, CBP treatment based on routine treatment can continue to clear the body of poison, shorten the course of disease and reduce the mortality rate.