肿瘤免疫主要由细胞免疫介导,肿瘤细胞具有免疫原性并能引起机体的抗肿瘤免疫应答,已是事实。越来越多的证据表明,淋巴细胞的特异性激活需要双信号刺激,一个是T细胞受体与同MHC结合的抗原肽复合物相互作用产生的特异性信号,另一个是共刺激分子同其配体结合产生的第二信号,即共刺激信号,协同淋巴细胞的激活。如果缺乏第二信号,可导致T淋巴细胞耐受 Tumor immunity is mainly mediated by cellular immunity, tumor cells are immunogenic and can cause the body’s anti-tumor immune response has been a fact. There is growing evidence that specific activation of lymphocytes requires two-signal stimulation, one is the specific signal generated by the interaction of T cell receptors with an antigenic peptide complex bound to MHC, and the other is the co-stimulatory molecule with its The second signal produced by ligand binding, a costimulatory signal, coordinates the activation of lymphocytes. The lack of a second signal can lead to T-lymphocyte tolerance