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检测54例乙肝患者血清LPO和红细胞SOD含量,并进行了动态观察。探讨了乙肝病人血清LPO与红细胞SOD水平的关系,LPO和SOD与ALT的关系。结果:三组乙肝血清LPO水平明显升高(P<0.01);慢重型乙肝LPO水平比急性和慢活型乙肝明显升高(P<0.01)。当ALT>200~u时LPO水平升高(P<0.05),<30~u时血清LPO水平差异不明显(P>0.05)。急性乙肝LPO上升,而红细胞SOD明显下降(P<0.01)。慢活型、慢重型乙肝比急性乙肝SOD水平升高、明显升高(P<0.05,P<0.01)。当ALT>200~u时红细胞SOD水平明显降低(P<0.01),200—30~u和<30~u者SOD水平显著升高(P<0.01)。乙肝恢复期(ALT<30~u时)血清LPO水平与正常人无差异(P>0.05),其中7例慢重型乙肝病情恶化时LPO水平持续高水平。乙肝病人红细胞SOD水平随病情的好转而上升(P<0.01)。结果表明,乙肝患者LPO水平高低可反映肝功能受损程度,特别是重型乙肝更为明显。而乙肝红细胞SOD水平升高和降低的论点待进一步验证。
The serum levels of LPO and erythrocyte SOD were measured in 54 patients with hepatitis B and the dynamic changes were observed. To investigate the relationship between serum LPO level and erythrocyte SOD level in hepatitis B patients and the relationship between LPO, SOD and ALT. Results: LPO levels in the three groups were significantly increased (P <0.01). The levels of LPO in chronic severe hepatitis B were significantly higher than those in acute and chronic hepatitis B (P <0.01). The level of LPO increased (P <0.05) when ALT> 200 u, while the level of serum LPO was not significantly different at 30 u (P> 0.05). Acute hepatitis B LPO increased, while erythrocyte SOD decreased significantly (P <0.01). Slow-acting and chronic hepatitis B were significantly higher than those of acute hepatitis B (P <0.05, P <0.01). When ALT> 200 ~ u, the level of SOD in erythrocytes was significantly decreased (P <0.01), SOD level was significantly increased in 200-30 ~ u and <30 ~ u (P <0.01). Serum LPO levels in HBeAg recovery group (ALT <30 u) were not significantly different from those in healthy controls (P> 0.05). Serum LPO levels remained high in seven patients with chronic severe hepatitis. Hepatitis B patients with erythrocyte SOD levels increased with the improvement of the disease (P <0.01). The results showed that the level of LPO in patients with hepatitis B can reflect the degree of impaired liver function, especially for severe hepatitis B is more obvious. The hepatitis B erythrocyte SOD level increased and decreased the argument to be further verified.