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观察改进的环磷酰胺（ＣＦＸ）冲击治疗难治性紫癜性肾炎（ＨＳＮ）的近期疗效。方法：对标准激素治疗效果差，蛋白尿＞２ｇ／ｄ及血尿２２例ＨＳＮ，用改进的ＣＴＸＸ冲击治疗ＣＴＸ８～１２ｍｇ次，连用２天，每半月１次，总量≤１５０ｍｇ／ｋｇ，以后每３个月１次，随访１２～３６个月。结果：治疗后完全缓解（蛋白尿＜０．３ ｇ／ｄ）１０例、显著缓解（０．３～０．９ｇ／ｄ）４例、缓解（１～２ｇ／ｄ）４例、无效（＞２ｇ／ｄ）４例，显著缓解率６３．６％，总有效率８１．８％；１７例血尿消失，有效率７７．３％。结论：ＣＴＸ冲击治疗难治性ＨＳＮ的近期疗效令人满意，远期疗效有待进一步验证。
To observe the short-term curative effect of modified cyclophosphamide (CFX) impact therapy on refractory purpura nephritis (HSN). Methods: The effect of standard hormone therapy was poor, proteinuria> 2g / d and hematuria in 22 cases of HSN, with CTXX CTXX impact treatment of CTX8 ~ 12mg times, once every 2 days, once every half month, the total ≤ 150mg / kg, 3 times a month, followed up for 12 to 36 months. Results: In the group of 10 cases with complete remission (proteinuria <0.3 g / d) after treatment, 4 cases were significantly relieved (0.3-0.9 g / d), 4 cases were relieved (1-2 g / d) 2g / d) 4 cases, the significant response rate was 63.6%, the total effective rate was 81.8%; 17 hematuria disappeared, the effective rate was 77.3%. Conclusion: The short-term curative effect of refractory HSN treated with CTX shock is satisfactory. The long-term curative effect needs to be further verified.