【摘 要】
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Cognition and pain share common neural substrates and interact reciprocally:chronic pain compromises cognitive performance,whereas cognitive processes modulate pain perception.In the present study,we established a non-drug-dependent rat model of context-b
【机 构】
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Neuroscience Research Institute, Peking University,Beijing 100083, China;Department of Clinical Medi
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Cognition and pain share common neural substrates and interact reciprocally:chronic pain compromises cognitive performance,whereas cognitive processes modulate pain perception.In the present study,we established a non-drug-dependent rat model of context-based analgesia,where two different contexts (dark and bright) were matched with a high (52℃) or low (48℃) temperature in the hot-plate test during training.Before and after training,we set the temperature to the high level in both contexts.Rats showed longer paw licking latencies in trials with the context originally matched to a low temperature than those to a high temperature,indicating successful establishment of a context-based analgesic effect in rats.This effect was blocked by intraperitoneal injection of naloxone (an opioid receptor antagonist) before the probe.The context-based analgesic effect also disappeared after optogenetic activation or inhibition of the bilateral infralimbic or prelimbic sub-region of the prefrontal cortex.In brief,we established a context-based,non-drug dependent,placebo-like analgesia model in the rat.This model provides a new and useful tool for investigating the cognitive modulation of pain.
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