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目的评价天津市2008年麻疹减毒活疫苗(measles attenuated live vaccine,MV)强化免疫活动(supplementary immunization activities,SIAs)的效果。方法利用MV SIAs接种资料、MV监测资料和现场督导资料,分析麻疹疫情的前后变化。结果天津市2008年MV SIAs报告接种率98.13%;疑似预防接种异常反应(adverse e-vents following immunization,AEFI)436例,发生率37.65/10万剂;疫苗效价监测为3.1 logTCID50/0.1ml;2009年报告麻疹188例(发病率1.60/10万),比2008年同期下降了92.33%。SIAs后<1岁组发病构成比为27.66%,≥15岁组为62.77%。结论天津市MV SIAs效果显著,高质量的SIAs是降低麻疹发病率的重要措施。<1岁和≥15岁人群将成为今后控制麻疹工作的重点。
Objective To evaluate the effect of 2008 measles attenuated live vaccine (MV) on supplementary immunization activities (SIAs). Methods MV SIAs inoculation data, MV monitoring data and on-site supervision data were used to analyze the changes before and after the outbreak of measles. Results The vaccination rate of MV SIAs in Tianjin in 2008 was 98.13%. A total of 436 suspected AECIs (AEFI) were reported, with a frequency of 37.65 / 100 000 doses. The vaccine titer was 3.1 log TCID 50 / 0.1 ml. In 2009, 188 cases of measles were reported (the incidence was 1.60 / 100,000), a decrease of 92.33% over the same period of last year. After SIAs <1 year old group incidence ratio was 27.66%, ≥15 years old group was 62.77%. Conclusion The MV SIAs in Tianjin are effective and high-quality SIAs are important measures to reduce the incidence of measles. <1-year-olds and ≥15-year-olds will be the focus of future measles control efforts.