肝硬化的早期临床诊断较困难 ,一般需作肝穿病理确诊 ,但肝穿有其损伤性 ,广泛开展受限制 ,故寻找一种敏感、可靠又无创伤的诊断方法是国内、外学者共同关注的课题。研究发现 ,细胞外间质成分（ＥＣＭ）ＨＡ、ＣⅣ、ＬＮ等是形成肝纤维化发生、发展中的关键 ,近年来发现测定血? The early clinical diagnosis of cirrhosis is more difficult and generally need to be diagnosed by liver biopsy, but the liver is punctuated by its injury and is widely limited. Therefore, finding a sensitive, reliable and non-invasive diagnostic method is a common concern of domestic and foreign scholars The subject. The study found that the extracellular matrix components (ECM) HA, C Ⅳ, LN is the formation of liver fibrosis, the key to the development in recent years found that the determination of blood?