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目的 探讨丙泊酚复合瑞芬太尼在急性颅脑损伤手术中的脑保护作用.方法 选取2014年1月-2015年12月在华北石油管理局总医院治疗的颅脑损伤患者共67例,根据使用麻醉药物不同将其随机分为观察组(36例)和对照组(31例),观察两组患者血流动力学(MAP,HR);炎性因子(TNF-α,IL-6,S-100β,NSE);麻醉恢复情况.结果 观察组术后24 hTNF-α,IL-6,S-100β,NSE均显著低于对照组(P＜0.05).麻醉苏醒时间和气管拔管时间观察组小于对照组,差异有统计学意义(P＜0.05).结论 丙泊酚复合瑞芬太尼麻醉对脑损伤患者具有一定脑保护作用,并有利于麻醉后苏醒.“,”Objective To study the protective effect of propofol and remifentanil in treatment of patients with acute brain injury, we began our study.Methods The patients with acute brain injury were diagnosed and treated in the General Hospital of North China Petroleum Bureau from January,2014 to December, 2015.According to the different anesthetic drugs, 67 patients were divided into the test group(n=36) and the control group (n=31).Results of vital signs(MAP and heart rate), TNF-a , IL-6, S-100β.NSE and post-anesthetic recovery in the two groups were compared.The statistical significance was P<0.05.Results TNF-a , IL-6, S-100 β and NSE after treatment in the test group were significantly lower than those in the control group(P<0.05).Anesthetic recovery time and extubation time were significantly lower than those in the control group(P<0.05).Conclusion Propofol and remifentanil suppressed patients with acute brain injury craniotomy inflammation and may have a cerebral protective effect.