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在人类中,乙肝病毒(HBV)是最普遍也是主要导致肝病的传染性病原体。之前的调查研究确认了长期乙肝病毒感染的患者不能将HBV完全从肝细胞清除。形成长期感染的主要机制尚未被阐明。然而研究者相信,和能够成功清除HBV感染的患者相比,那些患者基因和免疫参数的不同,可能是长期感染的原因。有研究证明,趋化因子在调节免疫细胞迁移和活化中有重要作用,并在抗HBV的全面免疫应答中是至关重要的。RANTES、MIP-1a和MIP-1b
In humans, hepatitis B virus (HBV) is the most prevalent and also a major infectious agent of liver disease. Previous research confirmed that patients with long-term hepatitis B virus infection can not completely remove HBV from liver cells. The main mechanism of long-term infection has not yet been clarified. However, researchers believe that differences in gene and immune parameters in those patients may be the cause of long-term infection, compared with those who can successfully clear HBV infection. Studies have shown that chemokines play an important role in the regulation of immune cell migration and activation and are crucial in the overall immune response against HBV. RANTES, MIP-1a and MIP-1b