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目的：观察吸入一氧化氮（ＮＯ）对烟雾吸入性损伤犬肺组织含水量的影响。方法：２１只犬随机分为３组：烟雾吸入后单纯吸氧〔氧浓度（ＦｉＯ２）０．４５〕为对照组（８只）；吸氧（ＦｉＯ２０．４５）＋０．００４５％ＮＯ为治疗组（９只），按时相点采血标本；正常组（４只）不致伤，用于建立组织学对照。动脉血浆胶体渗透压（ＣＯＰ）行多个样本均数间方差分析；支气管肺泡灌洗液（ＢＡＬＦ）中ＣＯＰ和蛋白质含量行两样本均数ｔ检验。结果：吸入ＮＯ治疗组血浆ＣＯＰ比对照组升高（Ｐ＜０．０５）；ＢＡＬＦ中ＣＯＰ比对照组略降低（Ｐ＞０．０５），而ＢＡＬＦ中蛋白质含量比对照组明显降低（Ｐ＜０．０５）；肺组织含水量略低于对照组（Ｐ＞０．０５）。结论：吸入ＮＯ对烟雾吸入性损伤犬肺组织含水量有减轻趋势，但尚无显著的效果，对其病理转归的影响仍难以定论，有待进一步深入研究。
Objective: To observe the effect of inhaled nitric oxide (NO) on the water content of lung tissue in smoky inhalation injury dogs. Methods: Twenty-one dogs were randomly divided into three groups: the rats in the control group (FiO2 0.45) were inhaled after smoke inhalation; FiO20.45 + 0.0045% (N = 9). Blood samples were taken on time point. Normal group (n = 4) was not injured and used to establish histological control. Arterial plasma colloid osmotic pressure (COP) was used to analyze the variance among multiple samples; COP and protein content in bronchoalveolar lavage fluid (BALF) were tested by two-sample mean t test. Results: Compared with control group, the COP of COPD rats in inhaled NO group was significantly higher than that in control group (P <0.05). The COP of BALF was slightly lower than that of control group (P> 0.05), while the protein content of BALF was significantly lower than that of control group (P < 0.05). The water content of lung tissue was slightly lower than that of the control group (P> 0.05). CONCLUSION: Inhalation of NO may reduce the water content of lung tissue in smoky inhalation injury dogs, but there is no significant effect on the pathological changes of the canines. It remains to be further studied.