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目的研究螺旋藻激酶(SPK)对血栓形成的影响及其作用机制。方法小鼠静脉注射螺旋藻激酶提取物,用毛细管法和玻片法比较生理盐水组与螺旋藻激酶组凝血时间;大鼠取血浆体外实验加入螺旋藻激酶提取物,体内股静脉注射螺旋藻激酶提取物,然后分别测定凝血时间(CT)、血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)及血浆凝血酶时间(TT),观察螺旋藻激酶提取物对血栓形成的作用。结果体外实验结果显示,PT分别为(23.84±3.26),(23.28±4.4),(57.64±6.69)m in;APTT分别为(23.94±3.27),(24.95±2.82),(37.15±5.96)m in;TT分别为(39.08±2.46),(69.18±5.05),(88.64±11.19)m in。体内实验PT分别为(15.66±0.56),(18.33±1.81),(57.64±6.69)m in;APTT分别为(23.94±3.27),(24.95±2.82),(37.15±5.96)m in,TT分别为(39.08±2.46),(69.18±5.05),(88.64±11.19)m in。表明螺旋藻激酶使小鼠血液凝固时间延长,并具有明显的剂量-效应依赖关系。结论螺旋藻蛋白激酶提取物具有明显抑制血栓形成的作用。
Objective To study the effect of spiramycin kinase (SPK) on thrombosis and its mechanism of action. METHODS: Spirulina kinase extract was injected intravenously in mice. The clotting time between saline group and spirulinaginase group was compared by capillary method and slide method; rat spirulina kinase extract was added in vitro and femoral vein injection of spirulina kinase was performed in vitro. The extracts were then assayed for clotting time (CT), plasma prothrombin time (PT), activated partial thromboplastin time (APTT), and plasma thrombin time (TT) to observe the effect of spirulina extract on thrombosis. . Results In vitro results showed that PT was (23.84±3.26), (23.28±4.4), (57.64±6.69) min, and APTT was (23.94±3.27), (24.95±2.82), (37.15±5.96) m, respectively. In; TT were (39.08 ± 2.46), (69.18 ± 5.05), (88.64 ± 11.19) min. The in vivo PT was (15.66±0.56), (18.33±1.81), (57.64±6.69) min, and the APTT was (23.94±3.27), (24.95±2.82), (37.15±5.96) min, respectively. It is (39.08±2.46), (69.18±5.05), (88.64±11.19) min. It was shown that Spirulina kinase prolongs blood clotting time in mice and has a significant dose-effect dependence. Conclusion Spirulina protein kinase extracts have obvious inhibitory effect on thrombosis.