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尿本周蛋白亦称游离轻链(free light chains,FLC),19世纪中叶其被首次描述并报道。自此以后,尿本周蛋白成为诊断多发性骨髓瘤(multiple myeloma,MM)的重要标志物。众所周知,免疫球蛋白(immunoglobulin,Ig)单体是由2条重链和2条轻链经二硫键连接而构成,其中轻链分为κ(Kappa)、λ(Lambda)2个型别,人体内两者的正常比例约为2∶1。正常人体每天产生约500 mg轻链,由于轻链的相对分子质量明显小于重链,故其合成速率大
Urine This week also called free light chains (free light chains, FLC), which was first described and reported in the mid 19th century. Since then, urine albumin has become an important marker for the diagnosis of multiple myeloma (MM). It is well-known that immunoglobulin (Ig) monomer is composed of two heavy chains and two light chains linked by disulfide bonds, wherein the light chain is divided into two types of kappa and lambda, The normal ratio of the two in the human body is about 2: 1. In normal humans, about 500 mg of light chain is produced each day. Since the relative molecular mass of the light chain is significantly smaller than that of the heavy chain, the rate of its synthesis is large