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对防治干预前的地方性砷中毒病区，居民手掌和足跖角化与居民饮用水砷含量、居民砷中毒检出率等进行了定量关系研究。手掌部和足跖部角化物检出率分别与饮周水砷含量、居民砷中毒检出率呈良好的正相关关系。采用直线或曲线回归建立了相应数学模式。角化严重程度亦和水砷及病情有关。水砷浓度高，角化程度亦重。中、重度角化主要发生在水砷0．4mg/L以上或砷中毒检出率在10％以上单位。手掌和足跖部角化发生率相互问亦是密切正相关关系。由于掌跖角化特别是手掌角化易于检查，在地方性砷中毒防治研究和监测中应将其列为常用指标。
Pre-interventional endemic arsenism wards, resident palm and plantar keratosis and drinking water arsenic content, the residents arsenic poisoning detection rate of quantitative relationship between the study. The detection rates of palpation and paw pedicle keratin showed a good positive correlation with the arsenic content in drinking water and the detection rate of arsenism in residents respectively. Using linear or curve regression to establish the corresponding mathematical model. The severity of keratosis is also related to water arsenic and its condition. High water arsenic concentration, keratosis degree is also heavy. Medium and severe keratosis occur mainly in water arsenic 0.4mg / L or more or arsenic poisoning detection rate of 10% or more units. The incidence of palmar and plantar keratosis is also closely related to each other. As the palmoplantar keratosis, especially the keratosis of the hand easy to check, in the prevention and treatment of endemic arsenic poisoning in the study and monitoring should be listed as a common indicator.