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目的:研究鼻型NK/T细胞淋巴瘤的免疫表型、病理特点、临床特点,以提高对本病的认识。方法:收集桂林医学院附院2003-2007年诊断的23例NK/T细胞淋巴瘤,用快捷免疫组织化学法进行TIA-1、CD56、CD3、CD20、CK、EBV抗体检测,并进行临床病理分析。结果:NK/T细胞淋巴瘤发生在鼻腔占69.6%(16/23),伴坏死、溃疡、鼻出血者占100%(23/23),肿瘤细胞嗜血管现象占39.1%(9/23),伴“鳞状细胞癌样反应”占21.74%(5/23)。TIA-1阳性率100%(23/23),CD3阳性率100%(23/23),CD56阳性率95.7%(22/23),EBV弱表达占21.7%(5/23),CD20阴性率100%(23/23),CK阴性率100%(23/23)。结论:临床及病理形态复杂多样性是NK/T细胞淋巴瘤的特点。病理诊断中须注意与炎症或高分化鳞状细胞癌鉴别。掌握组织形态的多样性,结合免疫表型特点:TIA-1、CD56、CD3阳性,CD20和CK阴性,是诊断NK/T细胞淋巴瘤的可靠依据。
Objective: To study the immunophenotype, pathological features and clinical features of nasal NK / T cell lymphoma to improve the understanding of this disease. Methods Totally 23 cases of NK / T cell lymphoma diagnosed from 2003 to 2007 in the Affiliated Hospital of Guilin Medical College were enrolled in this study. TIA-1, CD56, CD3, CD20, CK and EBV antibodies were detected by rapid immunohistochemistry analysis. Results: NK / T cell lymphoma accounted for 69.6% (16/23) of the nasal cavity, with necrosis, ulcer and nasal hemorrhage accounted for 100% (23/23), tumor cell vascularization accounted for 39.1% (9/23) , With “squamous cell carcinoma-like reaction ” accounted for 21.74% (5/23). The positive rate of TIA-1 was 100% (23/23), the positive rate of CD3 was 100% (23/23), the positive rate of CD56 was 95.7% (22/23), the weak expression of EBV was 21.7% (5/23) 100% (23/23), CK negative rate of 100% (23/23). Conclusion: The complicated clinical and pathological features are the hallmarks of NK / T cell lymphoma. Pathological diagnosis should pay attention to inflammation or differentiation of differentiated squamous cell carcinoma. Grasp the diversity of tissue morphology, combined with immunophenotype characteristics: TIA-1, CD56, CD3 positive, CD20 and CK negative, is a reliable basis for the diagnosis of NK / T cell lymphoma.