骨桥蛋白(osteopontin,OPN)是细胞外基质(ECM)中的一重要功能性蛋白,富含精氨酸-甘氨酸-天冬氨酸(Arg-Gly-Asp,RGD)序列。起初认为OPN参与骨的吸收,与骨组织的矿化有关,现发现OPN的RGD序列与许多细胞外基质蛋白的粘附序列相同,在人体组织中分布广泛,且具有多种功能,参与平滑肌 Osteopontin (OPN) is an important functional protein in extracellular matrix (ECM), which is rich in Arg-Gly-Asp (RGD) sequence. Initially OPN involved in the absorption of bone, and mineralization of bone tissue has been found, OPN RGD sequences and found that many of the extracellular matrix protein adhesion sequence the same in human tissue widely distributed and has a variety of functions involved in smooth muscle