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目的:观察伴附加染色体异常的急性早幼粒细胞白血病(APL)患者的临床特征、实验室检查、疗效及长期预后等。方法:回顾性分析64例单纯t(15;17)染色体易位APL患者和19例伴有附加染色体患者的临床资料。结果:伴有附加染色体异常发生率约为22.9%(19/83),其中+8染色体及del(9)异常多见,男性患者多于女性(15例∶4例)。与单纯t(15;17)染色体易位患者比较,伴有附加染色体患者的临床表现、实验室指标、疗效及长期预后等均差异无统计学意义。结论:伴有附加染色体异常发生率约为22.9%,其中男性多见,与单纯t(15;17)染色体易位APL患者比较,伴有附加染色体患者的临床表现、实验室检查、疗效及预后均差异无统计学意义,治疗方案无需调整。
Objective: To observe the clinical features, laboratory tests, curative effects and long-term prognosis of patients with acute promyelocytic leukemia (APL) with chromosomal abnormalities. Methods: The clinical data of 64 simple t (15; 17) chromosomal translocations APL patients and 19 patients with additional chromosomes were retrospectively analyzed. Results: The incidence of additional chromosomal abnormalities was about 22.9% (19/83). The abnormality of +8 chromosome and del (9) were more common in males than in females (15 cases: 4 cases). Compared with pure t (15; 17) chromosomal translocation patients, the clinical manifestations, laboratory parameters, curative effect and long-term prognosis of patients with additional chromosomes were not significantly different. CONCLUSIONS: The incidence of additional chromosomal abnormalities is about 22.9%, of which males are more common. Compared with simple t (15; 17) chromosomal translocations APL patients, the clinical manifestations, laboratory tests, curative effects and prognosis of patients with additional chromosomes No difference was found between the two groups. There was no need to adjust the treatment regimen.