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在迷走神经完整的家兔,以同样参数电流刺激左、右侧下丘脑对称部位(下丘脑外侧区和室旁核),均能诱发频发性心律失常(以室性与室上性期前收缩为主),但以左侧下丘脑刺激诱发期前收缩的次数较多,与右侧相比有显著差异。在迷走神经切断后刺激下丘脑早期(前5s 内)左侧下丘脑诱发的增压反应较显著,而右侧下丘脑诱发的心率增加较显著。分析刺激左、右侧下丘脑诱发期前收缩次数存在差异的机理,一方面可能由于左侧下丘脑经过同侧下行为主的心交感兴奋作用易致心律失常,另方面亦可能是由刺激左侧下丘脑早期有较显著的增压反应,使反射性迷走神经活动加强,与交感神经合并作用增加期前收缩的发生。实验结果提示,两侧下丘脑兴奋在诱发神经源性心律失常中以左侧下丘脑起较主要的作用。
In the vagus nerve intact rabbits, with the same parameters of current stimulation of left and right hypothalamic symmetry (hypothalamic lateral and paraventricular nucleus), can induce frequent arrhythmia (premature ventricular and supraventricular systolic Main), but to the left hypothalamic stimulation induced contraction more times, compared with the right there were significant differences. In the early hypothalamus (within the first 5 s), the hypothalamic-induced hypotensive response was more pronounced after vagotomy, while the right ventricle induced greater increase in heart rate. Analysis of left and right hypothalamic contractions before induction of the mechanism of the difference, on the one hand may be due to left hypothalamic ipsilateral descendants of the main sympathetic heart to stimulate the role of induced arrhythmia, the other may also be stimulated by the left Side of the hypothalamus in the early significant pressure response, the reflex vagus nerve activity increased, and the role of sympathetic increase the occurrence of pre-term contraction. The experimental results suggest that both hypothalamic excitations play a more important role in the left hypothalamus in inducing neurogenic arrhythmias.