白血病患者常伴有严重贫血、出血和感染,以往一般认为这是由于白血病细胞在造血组织中的过度增生,排挤了正常造血细胞生长的缘故,即正常造血受抑是由于白血病细胞物理性占位的结果。但是,在临床上也常见到骨髓并无广泛浸润,而正常血细胞却明显减少的病例。因此,近年来关于白血病细胞和正常造血细胞的关系,受到人们的重视。一、白血病细胞对CFU-S的影响由于检测人类CFU-S的方法尚未成功,所以有关CFU-S的材料均是从白血病动物身上获得的。Sainteny等观察了接种白血病细胞后AKR小鼠在发病过程中骨髓CFU-S数目的动态改变,发现受体小鼠在接种后5天内CFU-S无明显改变,大约为16个/10~5骨髓细胞;接种后7～14天,减少至9个;16～27天时 Leukemia patients are often accompanied by severe anemia, bleeding and infection, in the past that this is generally believed that this is due to leukemia cells in hematopoietic tissue hyperplasia, crowding out the normal growth of hematopoietic cells that suppress normal hematopoietic cells due to physical occupancy of leukemia cells the result of. However, it is also common in clinical cases that bone marrow is not extensively infiltrated but the number of normal blood cells is significantly reduced. Therefore, in recent years, the relationship between leukemia cells and normal hematopoietic cells has drawn people’s attention. I. EFFECTS OF LEUKEMIA CELLS ON CFU-S Since the method for detecting human CFU-S has not been successful, the material for CFU-S is obtained from leukemia animals. Sainteny et al observed the dynamic changes of the number of CFU-S in the bone marrow of AKR mice after vaccination with leukemia cells and found that there was no significant change of CFU-S in recipient mice within 5 days after inoculation, which was about 16 / 10-5 bone marrow Cells; 7 to 14 days after inoculation, reduced to 9; 16 to 27 days