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“新生儿败血症”系指婴儿在出生第一月中的细菌感染。侵入的最初部位常为血流,25～30%的病例可扩散至脑膜。全身性细菌病发生于1～10例/每千活婴,病例死亡率约从20%到>75%。本文重点复习过去十年间对此疾病的有关情况。病原学虽然过去50年中新生儿细菌性疾病的发病率维持不变,但致病菌却有相当大的改变,原因不明。在70年代,B族链球菌为大多数北美哺乳室中突出的致病原,现在约60%的新生儿败血症系大肠杆菌引起。在世界其他地区常见致病菌为B族链球菌,
“Neonatal sepsis” refers to the baby’s bacterial infection in the first month of life. The initial site of invasion is often blood flow, 25 to 30% of cases can spread to the meninges. Systemic bacterial disease occurs in 1 to 10 cases per 1000 live births, with case fatality rates ranging from about 20% to> 75%. This article focuses on the review of the disease over the past decade. Etiology Although the incidence of bacterial diseases in newborns has remained constant over the past 50 years, there have been considerable changes in pathogens, for unknown reasons. In the 1970s, group B streptococci were prominent causative agents in most North American nursing homes and about 60% of neonatal sepsis strains are now caused by E. coli. Common pathogenic bacteria in other parts of the world for Group B Streptococcus,