报道２５个Ｎ－甲基－Ｎ－（α－取代萘甲基）取代苄胺类化合物的合成及抗真菌活性。抑菌测试结果表明，目标化合物对于８种试验菌种均有不同程度的抑菌活性，化合物６，７，８，１０，１１和２１等活性为ｎａｆｔｉｆｉｎｅ的４～２０倍，化合物８，１０，１１和２１等活性为ｂｕｔｅｎａｆｉｎｅ的２～１０倍，化合物８，９，１０，１１和２１等对Ｓｐｏｒｏｔｒｉｃｈｕｍｓｃｈｅｎｃｋｉｉ及Ａｓｐｅｒｇｉｌｌｕｓｆｕｍｉｇａｔｕｓ的活性为ｃｌｏｔｒｉｍａｚｏｌｅ的８～１５倍，化合物７，８，９和２１等对Ｃｒｙｐｔｏｃｃｏｃｕｓｎｅｏｆｏｒｍａｎｓ亦表现出较高活性，ＭＩＣ为０．３１～１．２５μｇ·ｍｌ－１。 The synthesis and antifungal activities of 25 N-methyl-N- (α-substituted naphthylmethyl) substituted benzylamines were reported. The bacteriostasis test results showed that the target compounds exhibited antibacterial activity to 8 kinds of test strains to varying degrees. The activities of compounds 6, 7, 8, 10, 11 and 21 were 4 to 20 times higher than that of naftifine. The compounds 8, 10, 11 and 21 were 2 ~ 10 times higher than those of butenafine. Compounds 8, 9, 10, 11 and 21 showed 8-15 times higher activity against Sporotrichumschenckii and Aspergillusfumigatus than those of Cryptococus neoformans Showed higher activity, MIC was 0.31 ~ 1.25μg · ml-1.