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目的研究不同级别宫颈上皮内瘤变(cervical intraepithelial neoplasia,CIN)与人乳头瘤病毒(Human papil-lomavirus,HPV)基因型分布之间的关系。方法收集321例经组织病理学诊断确定为CIN2及以上(CIN2+)病人的宫颈分泌物标本,其中CIN2 67例,CIN3/ACIS 247例,浸润性宫颈癌7例。采用深圳亚能生物技术有限公司的人乳头瘤病毒(HPV)基因分型检测试剂盒对所选标本进行HPV检测及基因分型。结果在所有321例标本中,HPV阳性300例,阳性率93.5%,两型及两型以上感染138例,占比43.0%。HPV16最常见,检出率为41.1%(132/321),其次为HPV31,33,52,18和51。HPV16和33的单型感染在CIN3+中比CIN2更常见,具有统计学差异(P<0.05)。在包含有HPV16或HPV33的多型感染中,含有HPV16或HPV33的多型感染在CIN3+中比CIN2更常见,具有统计学意义(P<0.05)。结论 HPV16和HPV33比其他型别HPV具有更强的潜在致癌性。
Objective To investigate the relationship between different levels of cervical intraepithelial neoplasia (CIN) and the distribution of human papil-lomavirus (HPV) genotypes. Methods Cervical secretions were collected from 321 patients with CIN2 and above (CIN2 +) diagnosed by histopathology, of which 67 were CIN2, 247 were CIN3 / ACIS and 7 were invasive cervical cancer. Human papillomavirus (HPV) genotyping kit was used to detect and genotype HPV in selected samples. Results In all 321 cases, 300 were positive for HPV, the positive rate was 93.5%. 138 cases were infected by two or more types, accounting for 43.0%. The most common HPV16, the detection rate was 41.1% (132/321), followed by HPV31,33,52,18 and 51. Monotype infections with HPV16 and 33 were more common in CIN3 + than in CIN2, with statistical significance (P <0.05). Polymorphic infection with HPV16 or HPV33 was more common in CIN3 + than in CIN2, with statistical significance (P <0.05) among polytype infections with HPV16 or HPV33. Conclusion HPV16 and HPV33 have more potential carcinogenicity than other types of HPV.