五.ras族癌基因 ras癌基因已成为ras族癌基因,除Ha-ras,Ki-ras,N-ras,还有酵母的Ras-1,Ras-2。ras样蛋白的特点为具有高度保守性,如人的c-Ha-ras蛋白(p21~(Ha—ras)),小鼠肉瘤病毒的Ha-ras蛋白,和酵母的Ha-ras蛋白的氨基酸顺序有36％相同。 ras癌基因在许多肿瘤中都已被检定,被认为它与信号传导关系密切,因为牵连到磷酸肌醇和鸟苷三磷酸活化蛋白(GAP)的体系,所以ras基因的研究除了解肿瘤的发病机制外,还有可能解决细胞 V. ras gene oncogene ras oncogene has become a ras family of oncogenes, in addition to Ha-ras, Ki-ras, N-ras, there are yeast Ras-1, Ras-2. The ras-like proteins are characterized by a highly conserved amino acid sequence such as the human c-Ha-ras protein (p21 Ha-ras), the murine sarcoma virus Ha-ras protein, and the yeast Ha-ras protein 36% same. The ras oncogene has been identified in many tumors and is thought to have a close relationship with signal transduction because of the implicated phosphoinositide and guanosine triphosphate activating protein (GAP) systems, so ras gene research is not only to understand the pathogenesis of tumors In addition, it is possible to solve the cell